MDMA Impairs Response to Water Intake in Healthy Volunteers

Table 1

Pharmacokinetic results from Study 1. Values are given as mean ± SD. : area under the curve from 0 to extrapolated to infinity, : plasma clearance, : maximum plasma concentration, : time of maximum plasma concentration, : apparent volume of distribution, : first-order elimination constant, and : half-life.

Compound	Measure	Males		Females
		MDMA alone	Prazosin + MDMA	MDMA alone	Prazosin + MDMA
MDMA	(hng/mL)	3925 ± 1703	5156 ± 2971	3960 ± 1818	3701 ± 2151
	(L/h)	33.8 ± 9.3	30.6 ± 8.9	36.6 ± 31.0	36.7 ± 26.8
	(ng/mL)	241 ± 36	247 ± 53	222 ± 58	220 ± 58
	(1/h)	0.1 ± 0.02	0.08 ± 0.02	0.09 ± 0.02	0.1 ± 0.02
	(h)	7.7 ± 2.1	8.9 ± 2.4	7.7 ± 1.5	7.5 ± 2.2
	(h)	1.9 ± 0.4	2.4 ± 1.4	3.1 ± 1.1	2.7 ± 1.3
	(L)	353 ± 42	368 ± 60	361 ± 201	356 ± 164
MDA	(ng/mL)	15.2 ± 3.2	15 ± 3.8	16.4 ± 5.1	14.9 ± 4.8
	(hng/mL)	323 ± 120	337 ± 134	359 ± 126	325 ± 137
HMMA	(ng/mL)	226 ± 85	196 ± 89	183 ± 50	171 ± 58
	(hng/mL)	3404 ± 1120	3223 ± 1019	3196 ± 683	3004 ± 617
	(h)	1.8 ± 0.5	1.9 ± 1	1.9 ± 0.4	2.3 ± 0.7
HMA	(ng/mL)	4.1 ± 1	4 ± 0.8	4 ± 0.4	3.7 ± 0.9
	(hng/mL)	76.5 ± 34.2	81 ± 17.9	80.1 ± 12.1	87.5 ± 50.3