Research Article
Assessment of Prescriptions in the Endocrinology Department of a Tertiary Care Hospital in Pakistan Using World Health Organization Guidelines
| Degree of interaction | Interacting combination | Frequency (%) | Consequences |
| Minor | Aspirin + frusemide | 4 (3.6) | Combination effect level of potassium in serum affects CYP3A4 enzyme in liver antagonize hypoglycemic effect | Dexamethasone + omeprazole | 2 (1.8) | Insulin + frusemide | 6 (5.5) | Moderate | Glimepiride + aspirin | 1 (0.9) | Hypoglycemia chances | Dexamethasone + aspirin | 1 (0.9) | Peptic ulceration chances | Dexamethasone + clopidogrel | 1 (0.9) | Affects CYP3A4 enzyme in the liver | Dexamethasone + insulin | 1 (0.9) | Antagonize hypoglycemic effect | Major | Metformin + metformin | 1 (0.9) | Severe hypoglycemia chances | Heparin + aspirin + toradol | 1 (0.9) | Bleeding chances | Dexamethasone + hydrocortisone | 1 (0.9) | Steroid toxicity chances (cushing syndrome) | Dexamethasone + triamcinolone | 1 (0.9) | Total | | 20 (18.1) | |
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