Research Article
Assessment of Prescriptions in the Endocrinology Department of a Tertiary Care Hospital in Pakistan Using World Health Organization Guidelines
| | Degree of interaction | Interacting combination | Frequency (%) | Consequences |
| | Minor | Aspirin + frusemide | 4 (3.6) | Combination effect level of potassium in serum affects CYP3A4 enzyme in liver antagonize hypoglycemic effect | | Dexamethasone + omeprazole | 2 (1.8) | | Insulin + frusemide | 6 (5.5) | | Moderate | Glimepiride + aspirin | 1 (0.9) | Hypoglycemia chances | | Dexamethasone + aspirin | 1 (0.9) | Peptic ulceration chances | | Dexamethasone + clopidogrel | 1 (0.9) | Affects CYP3A4 enzyme in the liver | | Dexamethasone + insulin | 1 (0.9) | Antagonize hypoglycemic effect | | Major | Metformin + metformin | 1 (0.9) | Severe hypoglycemia chances | | Heparin + aspirin + toradol | 1 (0.9) | Bleeding chances | | Dexamethasone + hydrocortisone | 1 (0.9) | Steroid toxicity chances (cushing syndrome) | | Dexamethasone + triamcinolone | 1 (0.9) | | Total | | 20 (18.1) | |
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