Review Article
Advanced Development of the rF1V and rBV A/B Vaccines: Progress and Challenges
Table 2
Symptoms following aerosol exposure to BoNT/A1 or BoNT/B1.
| Symptoms | Human1 | NHP (rhesus macaque) | Guinea pig (Hartley) | Mouse (CD-1) | NHP (rhesus macaque) | Guinea pig (Hartley) | Mouse (CD-1) | | | Inhalational BoNT/A1 | Inhalational BoNT/B1 |
| Onset of symptoms: dose dependent | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Lethargy | Yes1 | Yes | Yes | NR | Yes | Yes | NR | Flaccid paralysis | Yes | NR | Yes | Yes | NR | NR | Yes | Ptosis (drooping eyelids) | Yes | Yes | Yes | Yes | Yes | Yes | No | Dysphagia (difficulty swallowing) | Yes1 | Yes | NR | NR | Yes | NR | NR | Symmetric, descending paralysis | Yes | Yes | NR | Yes | Yes | NR | NR | Labored respirations | NR2 | Yes | Yes | Yes | Yes | Yes | Yes | Ataxia | Yes1 | Yes | NR | NR | Yes | NR | NR | Muscle weakness | Yes1 | Yes | Yes | Yes | Yes | Yes | Yes | Lateral recumbency | NR | Yes | NR | NR | Yes | NR | NR | Nasal discharge | No | Yes | No? | NR | Yes | Yes | No | Constipation | Yes | Yes | NR | NR | NR | NR | NR | Paresis | Yes | Yes | Yes | Yes | Yes | Yes | NR | Coughing | No | Yes | NR | NR | Yes | No | NR | Piloerection | NR | NR | Yes | Yes | NR | Yes | Yes | Lethality | Yes | Yes | Yes | Yes | Yes | Yes | Yes | Time to death: dose dependent | NR | Yes | Yes | Yes | NR | NR | NR |
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1Specific observations in humans following inhalational exposure. 2NR, not reported.
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