Comparison of General Practice and Pharmaceutical Dispensing Data for Pharmacoepidemiological Research: Assessing the Risk of Urinary-Tract Infections with Sodium Glucose Cotransporter 2 Inhibitors for Diabetes

Table 3

Frequency of UTIs in the 6 months after SGLT2 or DPP-4 initiation.

	MedicineInsight data		10 PBS data
	SGLT2	DPP-4	SGLT2	DPP-4
	(N=1977)	(N=1964)	(N=3120)	(N=12359)
Proportion with at least one UTI	3.6 (N=71); Of those:	4.9 (N=97); Of those:	3.0 (N=94); Of those:	3.9 (N=479); Of those:
	89 had just one infection;	91 had just one infection;	83 had just one infection;	80 had just one infection;
	64 had the 1^st infection in the 12 weeks post index SGLT2	58 had the 1^st infection in the 12 weeks post index DPP-4	64 had the 1^st infection in the 12 weeks post index SGLT2	59 had the 1^st infection in the 12 weeks post index DPP-4

Note: Post-UTIs were identified only by medicines specific for UTIs (trimethoprim, nitrofurantoin, norfloxacin) in the 10 PBS data, while in the MedicineInsight data we accounted for UTI medicines (74 of all cases) and diagnosis/reasons for encounters (26 of all cases).
Terms used to identify UTIs in diagnoses and reason for encounters in MedicineInsight data: urinary tract infection, cystitis, genitourinary tract infection, pyelonephritis, urethritis, kidney infection, prostatitis.