(E)-N-Aryl-2-ethene-sulfonamide and its derivatives are potent anticancer agents; these compounds inhibit cancer cells proliferation. A study of quantitative structure-activity relationship (QSAR) has been applied on 40 compounds based on (E)-N-Aryl-2-ethene-sulfonamide, in order to predict their anticancer biological activity. The principal components analysis is used for minimizing the base matrix and the multiple linear regression (MLR) and multiple nonlinear regression have been used to design the relationships between the molecular descriptor and anticancer properties of the sulfonamide derivatives. The validation of the models MLR and MNLR has been done by dividing the dataset into training and test set, the external validation of multiple correlation coefficients was RpIC50 = 0.81 for MLR and RpIC50 = 0.91 for MNLR. The artificial neural network (ANN) showed a correlation coefficient close to 0.96, which concluded that this latter model is more effective and much better than the other models. This obtained model (ANN) has been confirmed by two methods of LOO cross-validation and scrambling (or Y-randomization). The high correlation between experimental and predicted activity values was observed, indicating the validation and the good quality of the derived QSAR model.

El Ghalia Hadaji

Mohamed Bourass

Abdelkarim Ouammou

Mohammed Bouachrine

Organic Compounds Based on (E)-N-Aryl-2-ethene-sulfonamide as Microtubule Targeted Agents in Prostate Cancer: QSAR Study

In this work, we synthesized In2S3 powder through chemical bath deposition method (CBD) in acid medium; we used thioacetamide as sulphide source and InCl3 as indium ion source. X-ray diffraction, diffuse reflection, and Raman spectroscopy measurements were used for In2S3 powder physicochemical characterization. Optical analysis indicated that In2S3 was active in the visible region of electromagnetic spectrum; it had a band gap of 2.47&#x2009;eV; the diffraction patterns and Raman spectroscopy suggested that powder had polycrystalline structure. Furthermore, we also studied the adsorption process of methylene blue (MB) on In2S3 powder; adsorption studies indicated that the Langmuir model describes experimental data. Finally, photocatalytic degradation of MB was studied under visible irradiation in aqueous solution; besides, pseudo-first-order model was used to obtain kinetic information about photocatalytic degradation; results indicated that the powder catalyst reduces 26&#x25; concentration of MB under visible irradiation.

William Vallejo

Carlos D&#xed;az-Uribe

Kathy Rios

Methylene Blue Photocatalytic Degradation under Visible Irradiation on In2S3 Synthesized by Chemical Bath Deposition

In this work, we fabricated system In(O,OH)S/i-ZnO/n+-ZnO to be used as potential optical window in thin films solar cells. i-ZnO/n+-ZnO thin films were synthesized by reactive evaporation (RE) method and In(O,OH)S thin films were synthesized by chemical bath deposition (CBD) method; all thin films were deposited on soda lime glass substrates. Thin films were characterized through X-ray diffraction (XRD), atomic force microscopy (AFM), and spectral transmittance measurements. Structural results indicated that both thin films were polycrystalline; furthermore, morphological results indicated that both thin films coated uniformly soda lime glass substrate; besides, optical characterization indicated that system had more than 80&#x25; of visible radiation transmittance.

Carlos Diaz-Uribe

G. Gordillo

Synthesis and Characterization of System In(O,OH)S/i-ZnO/n+-ZnO

Lawsonia inermis also known as henna was studied as a corrosion inhibitor for aluminum alloy in seawater. The inhibitor has been characterized by optical study via Fourier transform infrared spectroscopy (FTIR). The FTIR proves the existence of hydroxyl and carbonyl functional groups in Lawsonia inermis. Aluminum alloy 5083 immersed in seawater in the absence and presence of Lawsonia inermis was tested using electrochemistry method, namely, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PP). EIS and PP measurements suggest that the addition of Lawsonia inermis has caused the adsorption of inhibitor on the aluminum surface. The adsorption behavior of the inhibitor follow Langmuir adsorption model where the value of free energy of adsorption, <svg xmlns:xlink="http://www.w3.org/1999/xlink" xmlns="http://www.w3.org/2000/svg" style="vertical-align:-0.3499308pt" id="M1" height="8.98583pt" version="1.1" viewBox="-0.0498162 -8.6359 25.0488 8.98583" width="25.0488pt"><g transform="matrix(.013,0,0,-0.013,0,0)"><path id="g117-33" d="M535 230V280H52V230H535Z"/></g><g transform="matrix(.013,0,0,-0.013,7.631,0)"><path id="g113-133" d="M600 0V24L339 665L311 657L43 24V0H600ZM497 50H107L303 539L497 50Z"/></g><g transform="matrix(.013,0,0,-0.013,15.958,0)"><path id="g113-72" d="M673 297H417L411 270C517 261 522 258 506 183L487 92C476 38 428 19 360 19C207 19 123 132 123 287C123 472 243 631 441 631C557 631 617 583 617 469L647 472C650 545 655 604 658 632C625 643 554 666 467 666C201 666 23 502 23 278C23 90 156 -16 339 -16C410 -16 501 6 569 24C566 43 567 70 573 101L589 183C604 259 607 262 667 271L673 297Z"/></g></svg>, is less than 40 kJ/mol indicates that it is a physical adsorption. Finally, it was inferred that Lawsonia inermis has a real potential to act as a corrosion inhibitor for aluminum alloy in seawater.

F. Zulkifli

Nora&#x2019;aini Ali

M. Sukeri M. Yusof

Wan M. Khairul

Rafizah Rahamathullah

M. I. N. Isa

W. B. Wan Nik

The Effect of Concentration of Lawsonia inermis as a Corrosion Inhibitor for Aluminum Alloy in Seawater

Cathodic electrochemical deposition (CED) is introduced as an efficient and effective method for synthesis and surface coating of superparamagnetic iron oxide nanoparticles (SPIONs). In this way, bare Fe3O4 nanoparticles were electrosynthesized through CED method from aqueous solution Fe3+&#x2009;:&#x2009;Fe2+ chloride (molar ratio of 2&#x2009;:&#x2009;1). In the next step, the surface of NPs was coated with polyethyleneimine (PEI) and polyethylene glycol (PEG) during the CED procedure, and PEG/PEI coated SPIONs were obtained. The prepared NPs were evaluated by powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering (DLS), vibrating sample magnetometer (VSM), and field-emission scanning electron microscopy (FE-SEM). The pure magnetite phase and nanosize (about 15&#x2009;nm) of the prepared NPs were confirmed by XRD and FE-SEM. The presence of two coats (i.e., PEG and PEI) on the surface of electrosynthesized NPs was proved via FTIR results. The percentage of polymer coat (37.5&#x25;) on the NPs surface was provided by TGA analysis. The high magnetization value, negligible coercivity, and remanence measured by VSM indicate the superparamagnetic nature of both prepared NPs. The obtained results confirmed that the prepared Fe3O4 nanoparticles have suitable physicochemical and magnetic properties for biomedical applications.

Isa Karimzadeh

Mustafa Aghazadeh

Taher Doroudi

Mohammad Reza Ganjali

Peir Hossein Kolivand

Superparamagnetic Iron Oxide (Fe3O4) Nanoparticles Coated with PEG/PEI for Biomedical Applications: A Facile and Scalable Preparation Route Based on the Cathodic Electrochemical Deposition Method

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Advances in Physical Chemistry

Table of Contents

Table of Contents: 2017

Organic Compounds Based on (E)-N-Aryl-2-ethene-sulfonamide as Microtubule Targeted Agents in Prostate Cancer: QSAR Study

Methylene Blue Photocatalytic Degradation under Visible Irradiation on In₂S₃ Synthesized by Chemical Bath Deposition

Synthesis and Characterization of System In(O,OH)S/i-ZnO/n⁺-ZnO

The Effect of Concentration of Lawsonia inermis as a Corrosion Inhibitor for Aluminum Alloy in Seawater

Superparamagnetic Iron Oxide (Fe₃O₄) Nanoparticles Coated with PEG/PEI for Biomedical Applications: A Facile and Scalable Preparation Route Based on the Cathodic Electrochemical Deposition Method