Investigation of Antileishmanial Activities of Acridines Derivatives against Promastigotes and Amastigotes Form of Parasites Using Quantitative Structure Activity Relationship Analysis

Table 3

The absolute values of correlation coefficients with descriptors and activities.

Descriptors
Promastigotes
Henry’s law constant ()	0.130
Ideal gas thermal capacity (IGTC)	0.108
Number of H-Bond acceptors (NHA)	0.299
Number of H-Bond donors (NHD)	0.250
Balaban index ()	0.133
Shape coefficient ()	0.135
Total valence connectivity (TVC)	0.292
N%	0.238
H%	0.260
Gibbs free energy ()	0.119
Dipole moment ()	0.213
Electronegativity ()	0.599
Electrophilicity index ()	0.630
Molecular topological index (MTI)	0.116
Polar surface area (PSA)	0.282
Total connectivity (TC)	0.269
Wiener index ()	0.124
	0.554
	0.632
	0.227
Amastigotes
Total energy,	0.160
	0.286
Electronegativity ()	0.316
Polar surface area (PSA)	0.391
O%	0.105
Index of refraction ()	0.548
Density ()	0.242
Critical pressure (CP)	0.176
Gibbs free energy ()	0.195
Henry’s law constant ()	0.387
Number of H-Bond acceptors (NHA)	0.198
Number of H-Bond donors (NHD)	0.587
Number of rotatable bonds (NRB)	0.139
Sum of valence degrees (SVD)	0.146
Dipole moment ()	0.224
	0.338
Electrophilicity index ()	0.335
N%	0.436
C%	0.155
Surface tension ()	0.553
Boiling point (TB)	0.254
Critical temperature (CT)	0.276
Heat of formation ()	0.152
	0.248
Melting point ()	0.314
Partition coefficient (PC)	0.163
Shape coefficient ()	0.176
Winner index ()	0.103