Effect of Preoperative Antianxiety Medications on Blood Pressure and Blood Loss in Total Knee Arthroplasty: A Case-Control Study
Table 2
Two-way repeated measures analysis of variance for between treatment and time interactions.
F (df)
value
Systolic
Time
253.5 (2)
<0.001
Treatment
6.9 (1)
0.009
Timetreatment
2.1 (2)
0.126
Control
Bromazepam
Morning to baseline BP ratio
104.9 ± 13.2a,b,c
101.9 ± 12.4a,b,c
Preanesthesia to baseline BP ratio
125.6 ± 17.7a,b,c
119.7 ± 15.2a,b,c
Midoperation to baseline BP ratio
107.7 ± 17.2a,b,c
105.4 ± 14.9a,b,c
Diastolic
Time
119.8 (2)
<0.001
Treatment
8.2 (1)
0.004
Timetreatment
0.8 (2)
0.465
Control
Bromazepam
Morning to baseline BP ratio
105.2 ± 16.4a
101.3 ± 17.0a
Preanesthesia to baseline BP ratio
120.4 ± 20.5a,b
114.1 ± 17.9a,b
Midoperation to baseline BP ratio
106.4 ± 19.6b
101.5 ± 17.9b
Mean arterial pressure
Time
237.3 (2)
<0.001
Treatment
9.8 (1)
0.002
Timetreatment
1.7 (2)
0.192
Control
Bromazepam
Morning to baseline BP ratio
104.8 ± 12.7a
101.4 ± 13.0a
Preanesthesia to baseline BP ratio
122.5 ± 17.1a,b
116.3 ± 14.0a,b
Midoperation to baseline BP ratio
106.7 ± 16.7b
102.9 ± 14.5b
BP, blood pressure. All number as in mmHg; Statistically significant differences between the control and experimental groups at value less than 0.05; a,b,cStatistically significant differences between within-group blood pressure ratios at value less than 0.05.