Effect of Preoperative Antianxiety Medications on Blood Pressure and Blood Loss in Total Knee Arthroplasty: A Case-Control Study

Table 2

Two-way repeated measures analysis of variance for between treatment and time interactions.

	F (df)	value
Systolic
Time	253.5 (2)	<0.001
Treatment	6.9 (1)	0.009
Timetreatment	2.1 (2)	0.126
	Control	Bromazepam
Morning to baseline BP ratio	104.9 ± 13.2^a,b,c	101.9 ± 12.4^a,b,c
Preanesthesia to baseline BP ratio	125.6 ± 17.7^a,b,c	119.7 ± 15.2^a,b,c
Midoperation to baseline BP ratio	107.7 ± 17.2^a,b,c	105.4 ± 14.9^a,b,c
Diastolic
Time	119.8 (2)	<0.001
Treatment	8.2 (1)	0.004
Timetreatment	0.8 (2)	0.465
	Control	Bromazepam
Morning to baseline BP ratio	105.2 ± 16.4^a	101.3 ± 17.0^a
Preanesthesia to baseline BP ratio	120.4 ± 20.5^a,b	114.1 ± 17.9^a,b
Midoperation to baseline BP ratio	106.4 ± 19.6^b	101.5 ± 17.9^b
Mean arterial pressure
Time	237.3 (2)	<0.001
Treatment	9.8 (1)	0.002
Timetreatment	1.7 (2)	0.192
	Control	Bromazepam
Morning to baseline BP ratio	104.8 ± 12.7^a	101.4 ± 13.0^a
Preanesthesia to baseline BP ratio	122.5 ± 17.1^a,b	116.3 ± 14.0^a,b
Midoperation to baseline BP ratio	106.7 ± 16.7^b	102.9 ± 14.5^b

BP, blood pressure. All number as in mmHg; Statistically significant differences between the control and experimental groups at value less than 0.05; ^a,b,cStatistically significant differences between within-group blood pressure ratios at value less than 0.05.