Multiple Venous Thromboembolism Pharmacologic Agents Are Associated with an Increased Risk for Early Postoperative Complications following a Total Joint Arthroplasty

Table 4

Logistic regression analysis on increasing the number of VTE medications postoperatively.

Event	Risk factors
	BMI	Gender (female)	Age	ASA score	Inpatient postoperative prophylaxis count
Length of stay (logistic regression)	0.002 (1.021, 1.008–1.035)	<0.001 (2.208, 1.861–2.620	<0.001 (1.042, 1.033–1.051)	<0.001 (1.680, 1.435–1.966)	<0.001 (2.039, 1.747–2.378)
No 90-day postoperative events	0.719	0.315	0.876	0.014 (0.789 0.653–0.954)	<0.001 (0.675, 0.578–0.789)
Emergency department visit	0.629	0.772	0.525	0.223	0.005 (1.329, 1.088–1.623)
Readmit	0.465	0.416	0.010 (1.023, 1.006–1.041)	0.002 (1.668, 1.215–2.292)	0.010 (1.379, 10.78–1.762)
DVT	0.120	0.504	0.184	0.774	0.049 (1.541, 1.002–2.371)
UTI	0.962	0.448	0.267	0.444	0.011 (2.306, 1.212–4.389)
Death	0.954	0.309	0.598	0.003 (33.409, 3.318–336.402)	0.897
PE	0.183	0.761	0.706	0.186	<0.001 (8.147, 4.205–15.785)
Other return to the operating room	0.525	0.028 (1.713, 1.059–2.773)	0.003 (0.967, 0.946–0.989)	0.786	0.331
Hematoma	0.155	0.669	0.685	0.333	0.282
JSI	0.225	0.911	0.122	0.371	0.543
Transfusion	<0.001 (0.943, 0.918–0.969)	0.163	0.252	0.002 (1.611, 1.184–2.193)	<0.001 (1.646, 1.308–2.072)

Single values represent odds ratios. Multiple values represent value (odds ratio, confidence interval). ASA: American Society of Anesthesiologists; BMI: body mass index; DVT: deep vein thrombosis; JSI: joint space infection; PE: pulmonary embolism; UTI: urinary tract infection; VTE: venous thromboembolism. Controlling for BMI, gender, age, and preoperative ASA score, additional postoperative VTE medication, ranging 1 to 4, incrementally increases the risk for longer length of stay, chances for inpatient transfusion, 90-day postoperative event, DVT, PE, emergency department visit, and readmission.