The Impact of Preoperative Opioid Use Disorder on Complications and Costs following Primary Total Hip and Knee Arthroplasty
Table 2
Multivariate-adjusted analysis of complications in patients with and without opioid use disorder.
Complication
Nonopioid dependent
Opioid dependent
Odds ratioa
value (multivariate)
Prosthetic joint infection
22,702 (0.7%)
190 (1.9%)
1.55 (1.23–1.94)
<0.001
Superficial surgical site infection
24,020 (0.7%)
216 (2.2%)
1.66 (1.34–2.05)
<0.001
Noninfectious wound complication
30,492 (0.9%)
209 (2.1%)
1.40 (1.12–1.76)
0.003
Prosthetic complication
36,874 (1.1%)
217 (2.2%)
1.37 (1.10–1.70)
0.005
Revision
33,965 (1.0%)
238 (2.4%)
1.47 (1.19–1.81)
<0.001
Postoperative pain
135,788 (4.0%)
1,405 (14.3%)
2.97 (2.72–3.23)
<0.001
aOdds ratio with 95% confidence interval obtained through multivariate regression on matched cohorts while controlling for patient and operative characteristics.
