| Characteristic | Nonopioid dependent (n (%)) | Opioid dependent (n (%)) | value | Before matching | After matching |
| Total patients | | 3,428,273 (99.7) | 9,832 (0.3) | | |
| Surgery type | THA | 1,198,470 (35) | 4,258 (43.3) | <0.001 | 0.999 | TKA | 2,229,803 (65) | 5,574 (56.7) |
| Sex | Male | 1,347,632 (39.3) | 4,693 (47.7) | <0.001 | 0.999 | Female | 2,080,641 (60.7) | 5,140 (52.3) |
| Insurance | Medicare | 1,941,276 (56.7) | 4,576 (46.6) | <0.001 | 0.998 | Private | 1,226,412 (35.8) | 2,828 (28.8) | Medicaid | 118,405 (3.5) | 1,869 (19.0) | Other | 137,350 (4.0) | 552 (5.6) |
| Age category | <55 | 486,664 (14.2) | 3,550 (36.1) | <0.001 | 0.998 | 55–64 | 984,362 (28.7) | 3,852 (39.2) | 65–74 | 1,191,172 (34.7) | 1,810 (18.4) | 75–84 | 653,333 (19.1) | 540 (5.5) | 85+ | 112,742 (3.3) | 81 (0.8) |
| Perioperative transfusion | | 374,279 (10.9) | 1,463 (14.9) | <0.001 | 0.998 |
| Zip code income quartile | 1 | 728,949 (21.6) | 2,348 (24.3) | <0.001 | 0.997 | 2 | 861,933 (25.5) | 2,602 (26.9) | 3 | 900,568 (26.7) | 2,523 (26.1) | 4 | 886,595 (26.2) | 2,189 (22.7) |
| Hospital size | Low | 741,092 (21.6) | 1,278 (13.0) | <0.001 | 0.999 | Medium | 866,705 (25.3) | 2,596 (26.4) | High | 1,820,476 (53.1) | 5,958 (60.6) |
| Comorbidity | Obesity | 737,221 (21.5) | 2,920 (29.7) | <0.001 | 0.999 | Diabetes | 660,785 (19.3) | 1,626 (16.5) | <0.001 | 0.999 | Psychiatric disorder | 524,428 (15.3) | 3,961 (40.3) | <0.001 | 0.998 | Anemia | 490,946 (14.3) | 2,046 (20.8) | <0.001 | 0.999 | CHF | 87,133 (2.5) | 335 (3.4) | <0.001 | 0.998 | Renal failure | 165,033 (4.8) | 562 (5.7) | <0.001 | 0.999 | COPD | 507,748 (14.8) | 2,655 (27.0) | <0.001 | 0.999 | Tobacco use | 268,528 (7.8) | 3,028 (30.8) | <0.001 | 0.998 |
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