Long Term Anticoagulation (4–16 Years) Stops Progression of Idiopathic Hip Osteonecrosis Associated with Familial Thrombophilia
Table 2
Six patients, 9 hips (5 heterozygous for the V Leiden mutation, 1 with resistance to activated protein C). Anticoagulation for 4–16 years. Entry MRI and nonprogression by MRI.
Patient
Follow-up (years)
MRI finding at pretreatment entry
Progression by follow-up MRI at end of study
Number 1 (2 hips)
4
Osteonecrosis of right femoral head involving 25% of the superior articular surface Small subcentimeter focus of low T1 and T2 signal intensity (sclerosis) in the left femoral head
None in both hips
Number 2 (right hip)
4
Subchondral osteonecrosis measures approximately 1 cm transversely by 2.2 cm in the AP dimension
None in right hip
Number 3 (2 hips)
9
No subchondral collapse, serpiginous lesion with low signal intensity, confirming Ficat stage II by X-ray
No repeat MRI done
Number 4 (right hip)
13
Osteonecrosis of right femoral head involving 20% of the superior articular surface
None in right hip
Number 5 (2 hips)
13
Osteonecrosis of right femoral head involving 30% of the superior articular surface Osteonecrosis of left femoral head involving 30% of the superior articular surface
None in both hips
Number 6 (right hip)
16
Osteonecrosis of right femoral head involving 30% of superior articular surface
