Long Term Anticoagulation (4–16 Years) Stops Progression of Idiopathic Hip Osteonecrosis Associated with Familial Thrombophilia
Table 1
Six patients, 9 hips (5 heterozygous for the V Leiden mutation, 1 with resistance to activated protein C). Anticoagulation for 4 to 16 years. Symptoms, nonprogression by X-ray, and Ficat stages at entry and on follow-up.
Patient
Race sex
Age at entry
Follow-up yrs
Symptom improvement on long term anticoagulation
Progression by X-ray
Ficat stages at entry and on follow-up
Number 1 (2 hips)
WM
56
4
Symptom-free hips in 9 months No restriction in activities Full range of motion
None in both hips
Ficat II, right hip, Ficat I, left hip, unchanged
Number 2 (right hip)
WF
29
4
Symptom-free right hip in 3 months No restriction in activities
None in right hip
Ficat II, right hip, unchanged
Number 3 (2 hips)
WM
48
9
Symptoms persistent in both hips requiring Percocet No restriction in activities Full range of motion
None in both hips
Ficat II, both hips, unchanged
Number 4 (right hip)
BF
69
13
Symptom-free right hip in 16 months No restriction in activities Full range of motion
None in right hip
Ficat II, right hip, unchanged
Number 5 (2 hips)
WM
49
13
Symptom-free hips in 3 months No restriction in activities Full range of motion including rollerblading
None in both hips
Ficat II, both hips, unchanged
Number 6 (right hip)
WM
32
16
Symptom-free right hip in 3 months No restriction in activities Full range of motion including weight-lifting
