A Comparative Study of Interleukin 6, Inflammatory Markers, Ferritin, and Hematological Profile in Rheumatoid Arthritis Patients with Anemia of Chronic Disease and Iron Deficiency Anemia
Table 2
Comparative analysis of immunological and hematological marker indices in patients with IDA, RA-ACD, and RA-COMBI and healthy control group.
Parameter
IDA
RA-ACD
RA-COMBI
Control
P≤
1 vs 2
1 vs 3
1 vs 4
3 vs 4
3 vs 2
2 vs 4
No. patients
N=30
N=23
N=20
N=50
Sex, F/M
23/7
17/6
20/0
46/4
-
-
-
-
-
-
-
Age (years)
43±7.32
42.56±11.06
37.55±9.95
38.78±7.47
NS
NS
NS
NS
NS
NS
NS
Rang
(25-60)
(24-60)
(24-55)
(25-55)
WBC(/μ)
6.36±2.70
8.67±4.08
4.76±2.50
5.5±2.6
0.001
0.003
0.001
NS
0.001
0.001
0.001
RBC(/μL)
4.4±0.69
3.25±0.60
4.49±0.99
4.88±0.4
0.001
0.001
NS
0.002
NS
0.001
0.001
HGB (g/dl)
8.53±1.01
9.15±1.37
9.79±1.16
13.21±1.28
0.001
NS
0.001
0.001
0.001
NS
0.001
HCT (%)
27.86±2.39
28.46±4.96
31.54±9.51
41.41±3.83
0.001
NS
0.01
0.001
0.001
NS
0.001
MCV(fl)
64.4±8.95
85±6.24
74.7±4.8
87.64± 5.7
0.001
0.001
0.001
0.001
0.001
0.001
0.001
MCH (pg)
19.8±3.95
28.6±4.76
23.5±2.37
27.12±2.34
0.001
0.001
0.001
0.001
0.001
0.001
0.001
MCHC gl/dl
30.61±2.58
31.77±5.26
31.51±1.84
31.87±1.17
NS
NS
NS
NS
NS
NS
NS
ESR (mm/h)
6.1±1.2
72.56±30.5
63.5±36.9
7.98±3.7
0.001
0.008
NS
0.001
0.001
NS
0.001
hsCRP (mg/L)
1.26±0.96
7.09± 2.3
7.18±2.6
0.96±0.11
0.001
0.001
0.001
NS
0.001
NS
0.001
Anti-CCP (U/ml)
2.41±1.32
258.6±43.5
324.3±63.3
2.4±1.4
0.001
0.001
0.001
NS
0.001
NS
0.001
IL-6 (pg/ml)
2.18±1.4
431.3±52.2
459±61.8
4.94± 2.4
0.001
0.001
0.001
NS
0.001
NS
0.001
ferritin(ng/ml)
7.17±1.00
83.39±22.9
8.38±1.31
56.5±30.7
0.0001
0.001
NS
0.001
0.001
0.001
0.001
P is statistically significant among the groups at level< 0.05. Data are reported as mean ± standard deviation (range). Multiple comparisons among 4 groups depended on LSD. IDA: iron deficiency anemia; RA-ACD: anemia of chronic disease; RA-COMBI: combination of IDA and ACD. F: female; M: male.
