Anemia

Anemia / 2012 / Article / Tab 5

Research Article

Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease

Table 5

Multivariate linear regression showing relationship between Hemoglobin SS group, angiogenic growth factors, and CPC populations. SDF-1α was consistently associated with the relationship between Hemoglobin SS status and all CPC types (highlighted). Significant reductions in the beta-coefficient (>25%) compared to the main exposure variable are marked with an asterisk (*).

Outcome variables
Exposure variables CD34CD34/CXCR4CD34/VEGFR2CD34/CXCR4/VEGFR2
βAdj βAdj βAdj βAdj

Group = Hb SS0.940.191.240.281.450.291.060.14
Hb SS + Erythropoietin0.57*0.160.51*0.291.440.251.020.1
Hb SS + Angiopoietin-21.00.171.120.261.240.250.76*0.11
Hb SS + SDF-1α0.54*0.180.68*0.31.0*0.270.37*0.15
Hb SS + SDF-1α + Erythropoietin0.42*0.170.3*0.311.240.260.54*0.14
Hb SS + SDF-1α + Angiopoietin-20.710.190.73*0.290.98*0.260.3*0.14

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