Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease

Table 5

Multivariate linear regression showing relationship between Hemoglobin SS group, angiogenic growth factors, and CPC populations. SDF-1α was consistently associated with the relationship between Hemoglobin SS status and all CPC types (highlighted). Significant reductions in the beta-coefficient (>25%) compared to the main exposure variable are marked with an asterisk (*).

	Outcome variables
Exposure variables	CD34		CD34/CXCR4		CD34/VEGFR2		CD34/CXCR4/VEGFR2
	β	Adj 𝑟^2	β	Adj 𝑟^2	β	Adj 𝑟^2	β	Adj 𝑟^2
Group = Hb SS	0.94	0.19	1.24	0.28	1.45	0.29	1.06	0.14
Hb SS + Erythropoietin	0.57*	0.16	0.51*	0.29	1.44	0.25	1.02	0.1
Hb SS + Angiopoietin-2	1.0	0.17	1.12	0.26	1.24	0.25	0.76*	0.11
Hb SS + SDF-1α	0.54*	0.18	0.68*	0.3	1.0*	0.27	0.37*	0.15
Hb SS + SDF-1α + Erythropoietin	0.42*	0.17	0.3*	0.31	1.24	0.26	0.54*	0.14
Hb SS + SDF-1α + Angiopoietin-2	0.71	0.19	0.73*	0.29	0.98*	0.26	0.3*	0.14