Anemia

Anemia / 2012 / Article / Tab 3

Research Article

Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease

Table 3

Angiogenic growth factors and oxidant stress markers for each Hemoglobin Group. Children with Hemoglobin SS had higher levels of three angiogenic growth factors, higher cysteine and cystine, and lower oxidized glutathione than Controls. Significant differences in the geometric means between Control and Hemoglobin SS groups are indicated by asterisks (*).

Other exposure variablesMain exposure variables (Hemoglobin Group)
ControlHemoglobin SSFold difference value
Arithmetic mean (95th% CI)Geometric mean (95th% CI) Arithmetic mean (95th% CI)Geometric mean (95th% CI)

Erythropoietin (IU/mL)686.6 (4.8, 8.4)4.2 (3.2, 5.5)4272.4 (55.6, 89)56.6* (43.9, 73)13.5<0.001
Angiopoietin-2 (pg/mL)451922 (1343, 2501)1144 (809, 1616)275946 (4661, 7231)4968* (3820, 6461)4.3<0.001
SDF-1α (pg/mL)642376 (2192, 2561)2270 (2104, 2449)384065 (3660, 4471)3877* (3491, 4305)1.7<0.001
CyS (μM)448.0 (7, 9)7.4 (6.5, 8.4)1911.5 (9.5, 13.5)10.8* (9, 13)1.50.001
CySS (μM)4423.9 (22.3, 25.5)23.4 (21.9, 24.9)1934.6 (30.4, 38.8)33.7* (30, 37.8)1.5<0.001
(mV)44−81.1 (−84,–78)18− 87.1* (−92, −83)0.026
GSH (μM)441.1 (1, 1.2)1.0 (0.9, 1.2)191.1 (0.7, 1.5)0.89 (0.7, 1.2)0.38
GSSG (μM)440.1 (0.08, 0.1)0.08 (0.07, 0.1)190.08 (0, 0.17)0.04* (0.02, 0.07)0.50.002
(mV)44−117.2 (−121, −113)18124.1 (−132, −117)0.11
Urinary 8-isoprostanes (ng/mL)4015 (9.7, 20.2)8.88 (6.2, 12.7)168.9 (7.2, 10.5)8.4 (7, 10.1)0.83

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