Elevated Circulating Angiogenic Progenitors and White Blood Cells Are Associated with Hypoxia-Inducible Angiogenic Growth Factors in Children with Sickle Cell Disease

Table 2

Number of mononuclear cell colonies and CPCs for each Hemoglobin Group. Children with Hemoglobin SS had more mononuclear cell colonies and circulating progenitor cells than Controls. Mononuclear cell colonies are reported per well, and CPCs in cells/μL. Significant differences in geometric means between Control and Hemoglobin SS groups are indicated by asterisks (*).

	Main exposure variables (Hemoglobin Group)
Outcome variables	Control			Hemoglobin SS			Fold difference	𝑃 value
	𝑛	Arithmetic mean (95th% CI)	Geometric mean (95th% CI)	𝑛	Arithmetic mean (95th% CI)	Geometric mean (95th% CI)
Colonies	63	13.5 (8.5–18.5)	8.1 (5.8–11.5)	39	28.8 (16.1–41.6)	16.5* (11–24.6)	2	0.01
CD34	43	1.7 (1.3–2.1)	1.4 (1.2–1.7)	17	5.4 (2.3–8.5)	3.6* (2.3–5.6)	2.6	<0.001
CD34/CD133	43	1.0 (0.7–1.2)	0.8 (0.7–1.0)	17	2.0 (1.0–2.9)	1.3 (0.8–2.2)		0.1
CD34/CXCR4	43	0.6 (0.5–0.7)	0.48 (0.4–0.6)	17	3.2 (1.2–5.2)	1.66* (0.9–3.2)	3.5	<0.001
CD34/VEGFR2	43	0.12 (0.09–0.15)	0.08 (0.06–0.1)	17	0.68 (0.2–1.1)	0.36* (0.2–0.6)	2.6	<0.001
CD34/CXCR4/VEGFR2	43	0.2 (0.1–0.3)	0.1 (0.07–01)	17	0.6 (0.2–1)	0.29* (0.15–0.5)	2.9	0.002