Review Article
[Retracted] Plasmablastic Lymphoma: A Review of Current Knowledge and Future Directions
Table 1
The main differential diagnosis of PBL.
| Clinical presentation | Frequently oral cavity | Often extranodal (jaws and orbits) | Wide variety of presentations | Involves body cavity | Wide variety of presentations | BM (extramedullary in plasmacytoma) | BM (extramedullary in plasmacytoma) |
| Immunocompetency | +/− | ++ | +++ | +/− | + | ++ | ++ |
| Association with HIV | +++ | ++ | ++ | +++ | − | − | − |
| Association with HHV8 | +/− (usually −) | − | − | + | − | − | − |
| LCA | +/− | + | + | +/− | +/− | +/− | +/− |
| B-cell markers | | | | | | | | CD20 | − | + | + | +/− | − | − | − | CD79a | +/− (usually −) | + | + | − | − | +/− (usually −) | +/− (usually −) |
| CD138 | + | − | − | + | − | + | + | CD56 | +/− (usually −) | Rare + | Rare + | Rare + | +/− | Usually + | Usually + |
| Ki67 | High >70% | High >90% | High <90% | High >80% | High >80% | Low | High >70% |
| Other | BLIMP1+ | CD10 + | BCL-6 Usually + | CD30 Usually + | ALK+ | Serum M-spike CRAB | Serum M-spike CRAB |
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CRAB: hypercalcemia, kidney disease, anemia, and bone lytic lesions [67].
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