Autoimmune Diseases

Heat-shock Proteins in Autoimmunity


Publishing date
02 Nov 2012
Status
Published
Submission deadline
15 Jun 2012

1Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA

2Department of Rheumatology, King's College London, Hodgkin Building 3.60W, Guy's Campus, London SE1 1UL,UK

3Department of Cellular and Developmental Biology and STEMBIO, University of Palermo, Viale delle Scienze, 90128 Palermo, Italy

4Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, 9000 Ghent, Belgium

5Tel Aviv University, Israel


Heat-shock Proteins in Autoimmunity

Description

Heat shock proteins (HSPs), also known as “stress proteins,” are among the highly conserved and immunogenic proteins shared among diverse groups of microbial agents and mammals. Under physiological conditions, the ubiquitously distributed HSPs maintain the integrity and function of other cellular proteins under stressful conditions. However, HSPs also can become targets of immune response, resulting in immune pathology and clinical manifestations of autoimmunity. Importantly, HSPs are also capable of inducing immune responses that are immunoregulatory in nature, and certain HSPs can mediate resolution of the inflammatory responses. The main focus of this special issue will be on studies that advance our understanding of the role of HSPs in the pathogenesis of autoimmunity through induction/propagation as well as regulation/resolution of the disease-related processes. Also emphasized will be studies describing the use of HSPs for immunotherapeutic purposes.

We invite original articles and reviews describing the results of studies involving experimental models of autoimmunity and/or patients with autoimmune diseases. Examples of the related diseases include, but are not limited to rheumatoid arthritis, lupus, inflammatory myopathy, multiple sclerosis, and Type 1 diabetes. Potential Topics include, but are not limited to:

  • Experimental models of autoimmunity that involve HSP-driven immune responses in the induction, propagation, and regulation of the disease processes
  • The mechanisms describing the role of HSPs in the pathogenesis of autoimmunity, including the role of T cell vs. antibody-mediated responses, of the diversification (epitope spreading) of response
  • The immunological basis of spontaneous/experimental regression of acute inflammatory autoimmune disease, including the role of CD4+CD25+ regulatory T cells (Treg), Tr1, and so forth
  • The role of HSPs in the resolution of inflammatory responses in the course of autoimmunity
  • HSP-centered immune system networks (“Immunological homunculus”)
  • HSP-based strategies for immunomodulation and immunotherapy of autoimmunity.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ad/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ad/hsp/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 621417
  • - Editorial

Heat-Shock Proteins in Autoimmunity

Kamal D. Moudgil | Stephen J. Thompson | ... | Yehuda Shoenfeld
  • Special Issue
  • - Volume 2013
  • - Article ID 813256
  • - Review Article

Heat Shock Proteins and Regulatory T Cells

E. W. Brenu | D. R. Staines | ... | S. M. Marshall-Gradisnik
  • Special Issue
  • - Volume 2012
  • - Article ID 617213
  • - Review Article

The Immunosuppressive Activity of Heat Shock Protein 70

Pawel Stocki | Anne M. Dickinson
  • Special Issue
  • - Volume 2012
  • - Article ID 836519
  • - Review Article

Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation

Earl G. Noble | Garry X. Shen
  • Special Issue
  • - Volume 2012
  • - Article ID 502813
  • - Review Article

Heat Shock Proteins: Pathogenic Role in Atherosclerosis and Potential Therapeutic Implications

Arman Kilic | Kaushik Mandal
  • Special Issue
  • - Volume 2012
  • - Article ID 863041
  • - Review Article

CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity

Robert J. Binder | Yu Jerry Zhou | ... | Sudesh Pawaria
  • Special Issue
  • - Volume 2012
  • - Article ID 728605
  • - Review Article

Role of Hsp90 in Systemic Lupus Erythematosus and Its Clinical Relevance

Hem D. Shukla | Paula M. Pitha
  • Special Issue
  • - Volume 2012
  • - Article ID 105205
  • - Review Article

Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet’s Disease

Jun Shimizu | Tomoko Izumi | Noboru Suzuki
  • Special Issue
  • - Volume 2012
  • - Article ID 486069
  • - Review Article

Heat Shock Proteins, Autoimmunity, and Cancer Treatment

Stuart K. Calderwood | Mary Ann Stevenson | Ayesha Murshid
  • Special Issue
  • - Volume 2012
  • - Article ID 150824
  • - Review Article

M. paratuberculosis Heat Shock Protein 65 and Human Diseases: Bridging Infection and Autoimmunity

Coad Thomas Dow
Autoimmune Diseases
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