New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora

Figure 6

Exacerbating arthritis by oral administration of LPS in nonarthritic CIA mice. Mice were immunized with an emulsion of type II collagen and 1 mg/ml CFA. Nonarthritic mice failed to develop significant arthritis; however, the oral administration of LPS on day 42 induced severe arthritis in the nonarthritic mice (square), similar to the arthritic mice (circle).