New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora

Figure 5

Oral Collagen-Induced Arthritis (oral CIA) and nonantibody mediated LPS-induced arthritis. Oral administration of heterologous type II collagen for a prolonged period can elicit very mild arthritis (oral CIA) in mice, (a) and (b), compared with typical severe arthritis in general CIA without LPS injection (c).

(a)

(b)

(c)