New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora

<div>Synergistic effects of bacterial toxins to trigger and exacerbate arthritis in CAIA mice. CAIA in two mouse strains (DBA/1 and B10.RIII) was established by IV injection of the arthritogenic four-clone monoclonal antibody cocktail (1 mg) on day 0 and subsequent IP injection of 50 <i>μ</i>g of lipopolysaccharide (LPS) from <i>E. coli</i> (a), or mycoplasma arthritidis mitogen (MAM) (b) on day 3. Mice developed arthritis within 24–48 hours after receiving the toxins and the arthritic score plateaus 7-8 days later and can last up to 30 days. (a) mAb plus LPS in DBA/1 mice. (b) mAb plus MAM in B10.RIII mice.</div>

Autoimmune Diseases

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Figure 4: New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora 

Figure 4 | New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora 