New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora

Figure 3

Arthritis induced by the IV injection of an anti-type II collagen monoclonal antibody cocktail. Arthritis in DBA/1 mice on day 8 after the IV injection of the four-clone monoclonal antibody cocktail (10 mg), which recognizes the multispecies common epitope on the CB11 fragment of type II collagen. Mice developed polyarthritis in the paws.