Review Article

New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora

Figure 2

Localization of arthritogenic epitopes on cyanogen bromide (CB) digested type II collagen fragments (CB 6, 8, 9.7, 10, 11, and 12). The circles represent the epitopes of the arthritogenic monoclonal antibodies on endoproteinase (LysC)-digested CB11 fragments (LysC1, LysC2, and LysC3).