Presence of DQ2.2 Associated with DQ2.5 Increases the Risk for Celiac Disease
Table 1
CD predisposing HLA-DQ frequencies in CD patients and controls and general genetic risk.
Genotypes
DQB1*02 status
CD% ()
Control ()
CD/control
General risk
1 : 100
DQ2.5/DQ2.5
(β2/β2)
6.33% (15)
0.42% (1)
0.0004
1 : 7
DQ2.5/DQ2.2
(β2/β2)
25.31% (60)
2.53% (6)
<0.0001
1 : 10
DQ2.5/DQ8
(β2/x)
8.86% (21)
1.68% (4)
0.0007
1 : 19
DQ2.5
(β2/x) trans
10.54% (25)
2.11% (5)
0.0002
1 : 20
(β2/x) cis
32.91% (78)
11% (26)
<0.0001
1 : 30
DQ2.2/DQ8
(β2/x)
6.33% (15)
2.53% (6)
0.0718
1 : 40
DQ2.2/DQ2.2
(β2/β2)
0.84% (2)
2.11% (5)
0.4496
1 : 251
DQ8
—
3.8% (9)
10.97% (26)
0.0043
1 : 289
DQ2.2
(β2/x)
2.53% (6)
13.92% (33)
0.0001
1 : 550
DQ8/α5
—
0.42% (1)
4.22% (10)
0.0108
1 : 1005
α5
—
1.3% (3)
20.25% (48)
<0.0001
1 : 1594
Absent
—
0.84% (2)
25.31% (60)
<0.0001
1 : 3014
α8
—
0.0% (0)
2.95% (7)
0.0149
ND
ND: risk not determined; CD: celiac disease; β2 refers to DQB1*02; α5 refers to DQA1*05; α8 refers to DQA1*03:01; x denotes not determined allele; β2/β2 refers to DQB1*02 homozygosis; β2/x refers to DQB1*02 heterozygosis; value.
