Review Article
Role of Autoimmune Responses in Periodontal Disease
| Humoral | Cellular |
| () Antibody to aggregated IgG (rheumatoid factor) detected in gingiva and saliva | () Lymphocytotoxicity shown for oral epithelial cells | () Antibody levels to double stranded DNA were elevated in dog gingival | () Histological damage observed in gingival human fibroblasts with associated mononuclear cells | () Elevated levels of serum antibody to human collagen type I | () Lymphocytotoxic killing of autologous fibroblasts with associated mononuclear cells | () IgM, IgA rheumatoid factor antibody to human collagen types I and III produced by mononuclear cells | () Lymphoblastogenesis detected to native and denatured collagen | () Serum IgG antibodies to native and denatured types I and III bovine collagen detected in juvenile periodontitis | () Cellular immunity to proteoglycan detected in periodontal disease patients |
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