TY - JOUR A2 - Betterle, Corrado AU - Nair, Soumya AU - Faizuddin, Mohamed AU - Dharmapalan, Jayanthi PY - 2014 DA - 2014/05/25 TI - Role of Autoimmune Responses in Periodontal Disease SP - 596824 VL - 2014 AB - Periodontal diseases are characterized by localized infections and inflammatory conditions that directly affect teeth supporting structures which are the major cause of tooth loss. Several studies have demonstrated the involvement of autoimmune responses in periodontal disease. Evidences of involvement of immunopathology have been reported in periodontal disease. Bacteria in the dental plaque induce antibody formation. Autoreactive T cells, natural killer cells, ANCA, heat shock proteins, autoantibodies, and genetic factors are reported to have an important role in the autoimmune component of periodontal disease. The present review describes the involvement of autoimmune responses in periodontal diseases and also the mechanisms underlying these responses. This review is an attempt to throw light on the etiopathogenesis of periodontal disease highlighting the autoimmunity aspect of the etiopathogenesis involved in the initiation and progression of the disease. However, further clinical trials are required to strengthen the role of autoimmunity as a cause of periodontal disease. SN - 2090-0422 UR - https://doi.org/10.1155/2014/596824 DO - 10.1155/2014/596824 JF - Autoimmune Diseases PB - Hindawi Publishing Corporation KW - ER -