Review Article
An Update in the Use of Antibodies to Treat Glioblastoma Multiforme
Table 1
Classification of clinically used toxins based on their mechanism of action.
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Some immunotoxins are presented which have been used as toxin-based therapeutic approaches in the treatment of several malignancies acting on different intracellular targets. ADP: adenosine diphosphate; EF2: elongation factor 2 during protein synthesis on the ribosome; DT: diphtheria toxin; DT388 or DT389: truncated forms of DT without the receptor-binding activity; CRM107: cross-reacting material-mutant of DT without the receptor binding; PE: Pseudomonas exotoxin A; PE40 and PE38: truncated forms of PE without the receptor-binding domain Ia; CET40: cholera exotoxin A; RTA: ricin toxin A; HPR: human pancreatic ribonuclease A; ECP: eosinophilic cationic protein; EDN: eosinophil-derived neurotoxin. |