Clinical Study
Spondyloarthropathies in Autoimmune Diseases and Vice Versa
Table 1
Classification criteria for autoimmune diseases in humans. Comparison between ADs and autoinflammatory diseases.
| | | | Diseases | | | | SLE | RA | SS | AS | PsA | IBD |
| Direct proof | Antibody-mediated | Circulating ABs which alter the function | + | + | + | | | | Localized ABs | + | + | + | | | | IC located at lesion | + | + | + | + | | | Passive transference | + | | + | | | | Cells-mediated | In vitro T-cell proliferation in respond to autoantigen | + | | | | | | In vitro T-cell transference to immune-deficient mice | + | | | | | | In vitro T-cell cytotoxicity against target organ cells | + | + | + | | | |
| Indirect proof | | Disease reproduction by experimental immunization | + | + | + | + | + | + | Disease reproduction by idiotypes | + | + | | | | + | Spontaneous animal models | + | + | + | + | + | + | Animal models produced by immune system deregulation | + | + | + | + | + | + |
| Circumstantial evidence | | Auto-ABs | + | + | + | | | | Other AD association | + | + | + | | + | + | HLA association | + | + | + | + | + | + | Lymphocytic infiltration in target organ | + | + | + | + | + | | Good response to immune suppression | + | + | + | + | + | + |
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AS: ankylosing spondylitis, PsA: psoriatic arthritis, IBD: inflammatory bowel disease, SS: Sjögren’s syndrome, RA: rheumatoid arthritis, SLE: systemic lupus erythematosus, AD: autoimmune disease, ABs: antibodies, and IC: immune complexes.
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