Neurological Disorders in Primary Sjögren's Syndrome
Table 2
Antibodies in neurological manifestations of primary Sjögren’s syndrome.
Antibody
Clinical association
Reference
Anti-SSA and anti-SSB
Most of studies show lower prevalence of anti-SSA and anti-SSB antibodies in pSS with neurological involvement. In one series, patients with nonataxic sensory neuropathy had lower prevalence of anti-SSA (40% versus 72%) and anti-SSB (15% versus 41%).
This paper showed that anti-Ro antibodies were positive in 48% of patients with CNS compared to only 24% of all patients with pSS. However, the anti-SSA antibodies were detected by double immunodiffusion and not by ELISA.
In a large series of patients with neurological disorders (), these antibodies were detected in patients with pSS and neurological involvement, although the specificity has to be defined. Antiganglion neuron antibodies have been also reported.