Review Article
Heat Shock Proteins: Pathogenic Role in Atherosclerosis and Potential Therapeutic Implications
Table 1
Functions of heat shock proteins.
| Heat shock protein molecular weight (kilodaltons) | Function | Pathologic associations |
| 60 | Protein folding | Atherosclerosis | Protein unfolding | Rheumatoid arthritis | Polypeptide assembly | Systemic sclerosis | Protein translocation across membranes | Schizophrenia | | Diabetes mellitus |
| 10 | Cofactor for HSP 60 | Cardiovascular disease |
| 27 | Competes for uptake with lipids | Atherosclerosis | Estrogen receptor--associated protein | |
| 70 | Protein folding | Atherosclerosis | Protein unfolding | Leprosy | Degradation of misfolded or denatured proteins | Tuberculosis | Assembly of new proteins | | Translocation of proteins across membranes | |
| 90 | Molecular chaperone involved in protein folding and activation | Atherosclerosis | Systemic lupus erythematosus |
|
|