TY - JOUR A2 - Cervera, Ricard AU - Pérez-Pérez, María Elena AU - Avalos-Díaz, Esperanza AU - Herrera-Esparza, Rafael PY - 2012 DA - 2012/12/20 TI - Autoantibodies in Senear-Usher Syndrome: Cross-Reactivity or Multiple Autoimmunity? SP - 296214 VL - 2012 AB - Senear-Usher syndrome or pemphigus erythematosus is a pathology that overlaps clinically and serologically with pemphigus foliaceus and lupus erythematosus. Skin biopsies of patients with pemphigus erythematosus reveal acantholysis and deposits of immunoglobulins in desmosomes, and they are positive in the lupus band test. In the present paper, we determined whether the autoantibodies associated with pemphigus erythematosus targeted a single antigen or multiple antigens as a result of the stimulation of independent B cell clones. Our present paper demonstrates that patients with pemphigus erythematosus produce both antiepithelial antibodies specific for desmoglein 1 and 3 and antinuclear antibodies specific for Ro, La, Sm, and double-stranded DNA antigens. After eluting specific anti-epithelial or anti-nuclear antibodies, which were recovered and tested using double-fluorescence assays, a lack of cross-reactivity was demonstrated between desmosomes and nuclear and cytoplasmic lupus antigens. This result suggests that autoantibodies in pemphigus erythematosus are directed against different antigens and that these autoantibodies are produced by independent clones. Given these clinical and serological data, we suggest that pemphigus erythematosus behaves as a multiple autoimmune disease. SN - 2090-0422 UR - https://doi.org/10.1155/2012/296214 DO - 10.1155/2012/296214 JF - Autoimmune Diseases PB - Hindawi Publishing Corporation KW - ER -