Review Article
Pathogenic and Epiphenomenal Anti-DNA Antibodies in SLE
Table 2
DNA recognition and binding by anti-DNA autoantibodies.
| dsDNA | ssDNA |
| DNA-Recognition Mechanisms | DNA-Recognition Mechanisms | (i) Elusive | (i) Arginine involved [45] | DNA BINDING | DNA BINDING | (i) DNA phosphate backbone [61–63] | (i) Oligo-dT [17, 45] | (ii) Planted antigens [17] | (ii) Involvement of tryptophan and tyrosine in binding [17] | (iii) Cellular membrane proteins [65, 66] | DNA-binding MOTIFS | DNA-binding MOTIFS | (i) -cacc-caccc-accc-cccc blocks [60] | (i) gcg /cgcmotifs located in dsDNA [60]. | |
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