eIF4E Overexpression Is Associated with Poor Prognoses of Ovarian Cancer

Figure 1

When the 4EBP1 protein is phosphorylated by the AKT/mTOR signal pathway, eIF4E will be free from 4EBP1 to bind with eIF4G and then form the eIF4F complex, which subsequently promotes the translation of cap-dependent proteins. These special proteins could promote migration and abnormal proliferation and maintain the stemness of ovarian cancer cells.