Research Article

Fetal and Postnatal Nicotine Exposure Modifies Maturation of Gonocytes to Spermatogonia in Mice

Table 2

Evaluated parameters (median and interquartile ranges) in control and nicotine-exposed animals.

Age (dpp)Number of G in contact with BM/1000 μm2Number of G without contact with BM/1000 μm2Number of spermatogonia/1000 μm2Number of cells in proliferation/1000 μm2
ControlNicotineControlNicotineControlNicotineControlNicotine

30.978
0.363-2.254
0.534
0.273-1.352
0.416
0.343-1.156
0.654
0.307-1.515
10.380
6.817-14.000
6.072
2.539-9.539

71.645
0.708-3.606
0.859
0.328-1.926
0.010
0.010-0.343
0.409
0.353-0.873
0.144
0.123-0.364
0.108
0.088-0.140
1.1228
0.324-1.868
1.074
0.726-1.7462

100.010
0.010-0.612
0.199
0.124-0.406
1.291
1.003-1.665
1.066
0.398-1.701
5.122
1.396-8.267
3.162
0.317-8.605

161.712
0.937-3.210
1.378
1.005-1.761
2.114
1.965-2.787
1.784
1.093-2.290

350.912
0.524-1.489
0.517
0.216-0.892
6.809
5.157-9.583
5.040
3.102-7.630

control vs. nicotine of the same age. G = gonocyte; BM = basement membrane.