The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma

Table 6

Univariable and multivariable analyses for overall survival and progression-free survival.

Variable	Overall survival				Progression-free survival
	Univariable		Multivariable		Univariable		Multivariable
	Median	value	HR (95% CI)	value	Median	value	HR (95% CI)	value
Gender
Male	24	0.286			15	0.127
Female	36				18
Race
Han	24	0.604			18	0.515
Kazakh	24				13
Age (years)
<65	28	0.101			18	0.292
≥65	15				12
Tumor size
<3 cm	36	0.203			18	0.839
≥3 cm	20				15
Tumor site
Upper	36	0.31			48	0.178
Middle	20				12
Lower	24				18
Differentiation
Well	30	0.422			18	0.158
Moderate	21				14
Poor	24				20
pTNM		0.065				0.252
IB	34				36
IIA.B	24				16
IIIA.B,C	20				14
Lymph metastasis
Negative	34	0.006	0.75 (0.51-1.09)	0.131	24	0.005	0.912 (0.631-1.319)	0.626
Positive	18				12
Vascular invasion		0.011	0.60 (0.38-0.95)	0.03		0.008	0.616 (0.394-0.963)	0.033
Negative	24				18
Positive	14				12
Nerve invasion
Negative	24	0.02	0.76 (0.49-1.16)	0.204	15	0.369
Positive	14				16
Distant metastases		0.934				0.008	0.597 (0.395-0.903)	0.014
Negative	21				18
Positive	24				12
Treatment
Surgery	15	0.002	0.54(0.36-0.76)	0.001	13	0.259
Postoperative chemoradiotherapy	33				20
FGF2
Negative	40	<0.001	0.57 (0.32-1.01)	0.056	40	<0.001	0.183 (0.097-0.364)	<0.001
Positive	16				10
FGFR3
Negative	37	<0.001	0.69 (0.42-1.15)	0.157	37	<0.001	0.465 (0.281-0.769)	0.003
Positive	15				10
FGFBP1
Negative	38	<0.001	0.84 (0.48-1.49)	0.541	36	<0.001	0.870 (0.477-1.587)	0.65
Positive	14				12