The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma

Table 3

Relationship between expression of FGF2, FGFR3, and FGFBP1 in ESCC and clinicopathological parameters ().

Characteristic	Total	FGF2 expression			FGFR3 expression			FGFBP1 expression
		Negative	Positive		Negative	Positive		Negative	Positive
Gender				0.047			0.519			0.712
Male	129	36	93		44	85		46	83
Female	43	19	24		17	26		14	29
Race				0.794			0.033			0.302
Han	94	31	63		40	54		24	54
Hazak	78	24	54		21	57		36	58
Age (years)				0.053			0.384			0.045
<65	91	35	56		35	56		38	53
≥65	81	20	61		26	55		22	59
Tumor size				0.026			0.885			0.811
<3 cm	44	20	24		16	28		16	28
≥ 3 cm	128	35	93		45	83		44	84
Tumor site				0.902			0.548			0.457
Upper	8	3	5		4	4		4	4
Middle	95	31	64		35	60		35	60
Lower	69	21	48		22	47		21	48
Differentiation				0.231			0.043			0.012
Well	33	11	22		12	21		15	18
Moderate	97	35	62		43	54		41	56
Poor	42	9	33		6	36		4	38
Pathological stage				0.325			0.897			0.320
IB	12	6	6		5	7		6	6
IIA,B	86	28	58		30	56		32	54
IIIA,B,C	74	21	53		26	48		22	52
Lymph metastasis				0.007			0.078			0.032
Negative	113	44	69		45	68		45	68
Positive	59	11	48		16	43		15	48
Vascular invasion				0.644			0.68			0.735
Negative	141	44	97		51	90		50	91
Positive	31	11	20		10	21		10	21
Nerve invasion				0.313			0.764			0.826
Negative	136	46	90		49	87		48	88
Positive	36	9	27		12	24		12	24
Distant metastases				0.142			0.494			0.718
Negative	132	46	86		45	87		47	85
Positive	40	9	31		16	24		13	27