Research Article
Computational Analysis Reveals the Association of Threonine 118 Methionine Mutation in PMP22 Resulting in CMT-1A
Table 3
The
score,
score, molecular variations, and prediction reliability calculated from MutPred server.
| SNP ID | Mutations | score | score | MutPred | Prediction reliability |
| rs28936682 | R157W | 0.887 | 0.0022 | Loss of disorder | Very confident hypotheses | rs104894617 | L16P | 0.939 | 0.0826 | Loss of stability | No reliable inference | rs104894618 | S79C | 0.936 | 0.0098 | Gain of catalytic residue | Very confident hypotheses | rs104894619 | T118M | 0.948 | 0.0045 | Loss of sheet | Very confident hypotheses | rs104894620 | M69K | 0.943 | 0.0325 | Loss of stability | Confident hypotheses | rs104894622 | H12Q | 0.894 | 0.0865 | Gain of catalytic residue | No reliable inference | rs104894625 | S22F | 0.873 | 0.0028 | Gain of disorder | No reliable inference | rs104894624 | G150C | 0.966 | 0.0510 | Loss of glycosylation at S149 | No reliable inference | rs104894626 | W28R | 0.951 | 0.0344 | Loss of sheet | Confident hypotheses | rs104894627 | D37V | 0.957 | 0.0521 | Loss of disorder | No reliable inference | rs375449671 | Y136S | 0.758 | 0.0130 | Loss of stability | Actionable hypotheses |
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