Computational Analysis Reveals the Association of Threonine 118 Methionine Mutation in PMP22 Resulting in CMT-1A

Table 3

The score, score, molecular variations, and prediction reliability calculated from MutPred server.

SNP ID	Mutations	score	score	MutPred	Prediction reliability
rs28936682	R157W	0.887	0.0022	Loss of disorder	Very confident hypotheses
rs104894617	L16P	0.939	0.0826	Loss of stability	No reliable inference
rs104894618	S79C	0.936	0.0098	Gain of catalytic residue	Very confident hypotheses
rs104894619	T118M	0.948	0.0045	Loss of sheet	Very confident hypotheses
rs104894620	M69K	0.943	0.0325	Loss of stability	Confident hypotheses
rs104894622	H12Q	0.894	0.0865	Gain of catalytic residue	No reliable inference
rs104894625	S22F	0.873	0.0028	Gain of disorder	No reliable inference
rs104894624	G150C	0.966	0.0510	Loss of glycosylation at S149	No reliable inference
rs104894626	W28R	0.951	0.0344	Loss of sheet	Confident hypotheses
rs104894627	D37V	0.957	0.0521	Loss of disorder	No reliable inference
rs375449671	Y136S	0.758	0.0130	Loss of stability	Actionable hypotheses