Computational Analysis Reveals the Association of Threonine 118 Methionine Mutation in PMP22 Resulting in CMT-1A

Table 1

nsSNPs of PMP22 gene analyzed by three computational methods: PolyPhen 2.0, SIFT, and PMUT.

SNP ID		SIFT			PolyPhen2		PMUT
	Mutation	Score	Prediction	PSIC	Prediction	Score	Prediction
rs28936682	R157W	0.00	Deleterious	1.000	Probably damaging	0.9963	Pathological
rs104894617	L16P	0.03	Deleterious	0.928	Possibly damaging	0.7069	Pathological
rs104894618	S79C	0.02	Deleterious	0.992	Probably damaging	0.5895	Pathological
rs104894619	T118M	0.00	Deleterious	1.000	Probably damaging	0.6326	Pathological
rs104894620	M69K	0.01	Deleterious	0.994	Probably damaging	0.8504	Pathological
rs104894621	S72L	0.00	Deleterious	0.999	Probably damaging	0.4180	Neutral
rs104894622	H12Q	0.01	Deleterious	0.546	Possibly damaging	0.5511	Pathological
rs104894623	A67T	0.00	Deleterious	1.000	Probably damaging	0.1614	Neutral
rs104894624	G150C	0.02	Deleterious	1.000	Probably damaging	0.9706	Pathological
rs104894625	S22F	0.00	Deleterious	0.960	Probably damaging	0.8126	Pathological
rs104894626	W28R	0.00	Deleterious	1.000	Probably damaging	0.9771	Pathological
rs104894627	D37V	0.01	Deleterious	1.000	Probably damaging	0.6415	Pathological
rs11545341	Q86K	0.12	Tolerated	0.997	Probably damaging	0.5282	Pathological
rs112232836	K92R	0.27	Tolerated	0.998	Probably damaging	0.0661	Neutral
rs112651887	T44A	0.51	Tolerated	0.001	Benign	0.0557	Neutral
rs138515303	I9V	0.35	Tolerated	0.041	Benign	0.0326	Neutral
rs140763467	G133S	0.06	Tolerated	1.000	Probably damaging	0.8228	Pathological
rs141094419	A135T	0.09	Tolerated	0.001	Benign	0.6424	Pathological
rs147114400	L90V	0.08	Tolerated	0.476	Possibly damaging	0.2900	Neutral
rs148822354	A115V	1.00	Tolerated	0.005	Benign	0.4346	Neutral
rs189205303	T89N	0.11	Tolerated	0.997	Probably damaging	0.4841	Neutral
rs201255121	P144T	0.31	Tolerated	1.000	Probably damaging	0.5560	Pathological
rs368223794	A106T	0.30	Tolerated	0.865	Possibly damaging	0.2658	Neutral
rs368908933	H51R	0.33	Tolerated	0.000	Benign	0.1470	Neutral
rs373322590	N32S	0.47	Tolerated	0.011	Benign	0.1235	Neutral
rs375449671	Y136S	0.00	Deleterious	0.636	Possibly damaging	0.7302	Pathological