TY - JOUR A2 - Di Maro, Antimo AU - Ukoha, U. U. AU - Mbagwu, S. I. AU - Ndukwe, G. U. AU - Obiagboso, C. PY - 2015 DA - 2015/11/17 TI - Histological and Biochemical Evaluation of the Kidney following Chronic Consumption of Hibiscus sabdariffa SP - 486510 VL - 2015 AB - Hibiscus sabdariffa L. has been used traditionally as herbal medicine and has been documented to have a broad range of therapeutic effects. The present study aimed to investigate the effects of chronic administration of aqueous extract of flowers of Hibiscus sabdariffa on the histology of the kidney and some biochemical indices of renal function in male Wistar rats. Twenty (20) Wistar rats were randomly divided into four (4) groups of five rats each. The extract was administered orally in doses 200, 500, and 800 mg/kg body weight for 21 days. The kidney was harvested and processed histologically and blood samples were taken for biochemical assays. The histological results showed dose dependent pathological states and the biochemical analysis revealed a dose dependant variation in renal indices. These results suggest that chronic administration of aqueous extract of Hibiscus sabdariffa may be toxic to the kidney. SN - 2356-6582 UR - https://doi.org/10.1155/2015/486510 DO - 10.1155/2015/486510 JF - Advances in Biology PB - Hindawi Publishing Corporation KW - ER -